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This exception allows an Institutional Review Board (IRB) to approve research without requiring that informed consent be obtained if it finds, among other things, that the human subjects are in a life-threatening situation, available treatments are unproven or unsatisfactory, obtaining informed consent is not feasible, participation in the research holds out the prospect of direct benefit to the subjects, the research could not practicably be carried out without the waiver, and other protections are provided. A retrospective study in a MRFIT clinical center. Seronegative rheumatoid arthritis is the rheumatoid arthritis in which the blood doesn’t contain rheumatoid factor (rf or rhf).
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